Risk factors for headache chronification

Ann I. Scher, Lynn A. Midgette, Richard B. Lipton

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations


About 4% of the adult population and about 1% to 2% of children experience chronic attacks on a daily or near daily basis. While there is uncertainty about the biological mechanisms that lead to headache "chronification," the epidemiologic literature has provided some insight into modifiable and nonmodifiable factors that appear to influence risk of headache progression. This review summarizes the evidence from population-based studies related to the chronic daily headache phenotype, natural history, and risk factors that may influence incidence, prevalence, or prognosis.

Original languageEnglish (US)
Pages (from-to)16-25
Number of pages10
Issue number1
StatePublished - Jan 2008


  • Chronic daily headache
  • Epidemiology
  • Risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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