Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents

Andreas N. Madsen; Jacob Jelsing; Esther H.E.M. van de Wall; Niels Vrang; Philip J. Larsen; Gary J. Schwartz

doi:10.1016/j.neulet.2008.10.001

Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents

Andreas N. Madsen, Jacob Jelsing, Esther H.E.M. van de Wall, Niels Vrang, Philip J. Larsen, Gary J. Schwartz

Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The selective CB1 receptor antagonist rimonabant is a novel weight control agent. Although CB1 receptors and binding sites are present in both the rodent central and peripheral nervous systems, including the afferent vagus nerve, the role of gut afferents in mediating anorexia following CB1R blockade is still debated. In the present study we examined rimonabant-induced anorexia in male C57BL/6J mice with subdiaphragmatic vagotomy (VGX) as well as in male Sprague-Dawley rats subjected to either subdiaphragmatic vagal deafferentation (SDA) alone or in combination with a complete celiac-superior mesenteric ganglionectomy (CGX). Irrespective of the operational procedure, rimonabant (10 mg/kg) effectively reduced standard chow as well as palatable diet (ensure) intake. In conclusion, the data clearly demonstrate that neither vagal gut afferents, nor gut afferents traveling via the sympathetic nervous system, are required for rimonabant to inhibit food intake leading to the hypothesis that centrally located CB1 receptors are the prime mediators of rimonabant-induced anorexia.

Original language	English (US)
Pages (from-to)	20-23
Number of pages	4
Journal	Neuroscience Letters
Volume	449
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2008.10.001
State	Published - Jan 2 2009

Keywords

Food intake
Meal pattern
Obesity
Vagotomy
Visceral afferents

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neulet.2008.10.001

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title = "Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents",

abstract = "The selective CB1 receptor antagonist rimonabant is a novel weight control agent. Although CB1 receptors and binding sites are present in both the rodent central and peripheral nervous systems, including the afferent vagus nerve, the role of gut afferents in mediating anorexia following CB1R blockade is still debated. In the present study we examined rimonabant-induced anorexia in male C57BL/6J mice with subdiaphragmatic vagotomy (VGX) as well as in male Sprague-Dawley rats subjected to either subdiaphragmatic vagal deafferentation (SDA) alone or in combination with a complete celiac-superior mesenteric ganglionectomy (CGX). Irrespective of the operational procedure, rimonabant (10 mg/kg) effectively reduced standard chow as well as palatable diet (ensure) intake. In conclusion, the data clearly demonstrate that neither vagal gut afferents, nor gut afferents traveling via the sympathetic nervous system, are required for rimonabant to inhibit food intake leading to the hypothesis that centrally located CB1 receptors are the prime mediators of rimonabant-induced anorexia.",

keywords = "Food intake, Meal pattern, Obesity, Vagotomy, Visceral afferents",

author = "Madsen, {Andreas N.} and Jacob Jelsing and {van de Wall}, {Esther H.E.M.} and Niels Vrang and Larsen, {Philip J.} and Schwartz, {Gary J.}",

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AU - Madsen, Andreas N.

AU - Jelsing, Jacob

AU - van de Wall, Esther H.E.M.

AU - Vrang, Niels

AU - Larsen, Philip J.

AU - Schwartz, Gary J.

PY - 2009/1/2

Y1 - 2009/1/2

N2 - The selective CB1 receptor antagonist rimonabant is a novel weight control agent. Although CB1 receptors and binding sites are present in both the rodent central and peripheral nervous systems, including the afferent vagus nerve, the role of gut afferents in mediating anorexia following CB1R blockade is still debated. In the present study we examined rimonabant-induced anorexia in male C57BL/6J mice with subdiaphragmatic vagotomy (VGX) as well as in male Sprague-Dawley rats subjected to either subdiaphragmatic vagal deafferentation (SDA) alone or in combination with a complete celiac-superior mesenteric ganglionectomy (CGX). Irrespective of the operational procedure, rimonabant (10 mg/kg) effectively reduced standard chow as well as palatable diet (ensure) intake. In conclusion, the data clearly demonstrate that neither vagal gut afferents, nor gut afferents traveling via the sympathetic nervous system, are required for rimonabant to inhibit food intake leading to the hypothesis that centrally located CB1 receptors are the prime mediators of rimonabant-induced anorexia.

AB - The selective CB1 receptor antagonist rimonabant is a novel weight control agent. Although CB1 receptors and binding sites are present in both the rodent central and peripheral nervous systems, including the afferent vagus nerve, the role of gut afferents in mediating anorexia following CB1R blockade is still debated. In the present study we examined rimonabant-induced anorexia in male C57BL/6J mice with subdiaphragmatic vagotomy (VGX) as well as in male Sprague-Dawley rats subjected to either subdiaphragmatic vagal deafferentation (SDA) alone or in combination with a complete celiac-superior mesenteric ganglionectomy (CGX). Irrespective of the operational procedure, rimonabant (10 mg/kg) effectively reduced standard chow as well as palatable diet (ensure) intake. In conclusion, the data clearly demonstrate that neither vagal gut afferents, nor gut afferents traveling via the sympathetic nervous system, are required for rimonabant to inhibit food intake leading to the hypothesis that centrally located CB1 receptors are the prime mediators of rimonabant-induced anorexia.

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KW - Meal pattern

KW - Obesity

KW - Vagotomy

KW - Visceral afferents

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Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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