Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus

Marla J. Keller; Mary E. Klotman; Betsy C. Herold

doi:10.1093/jac/dkg214

Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus

Marla J. Keller, Mary E. Klotman, Betsy C. Herold

Pediatrics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In summary, more extensive pre-clinical evaluation of SAMMA and other microbicides in development is required. The activity against primary isolates in the presence of genital tract fluids and over a broad pH range should be carefully evaluated. Optimization of formulations will require more attention. Formulation characteristics affecting microbicide efficacy include hydrophilicity, dispersibility, viscosity and bioadhesion. Development and standardization of human explant cultures and animal models to test the efficacy and safety of formulated compounds is essential. Pilot in vivo studies focusing on a thorough investigation of the changes in inflammatory cells and cytokines following topical application of candidate agents are recommended before the initiation of large-scale clinical trials.

Original language	English (US)
Pages (from-to)	1099-1102
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	51
Issue number	5
DOIs	https://doi.org/10.1093/jac/dkg214
State	Published - May 1 2003

Keywords

HIV
Microbicides

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jac/dkg214

Cite this

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title = "Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus",

abstract = "In summary, more extensive pre-clinical evaluation of SAMMA and other microbicides in development is required. The activity against primary isolates in the presence of genital tract fluids and over a broad pH range should be carefully evaluated. Optimization of formulations will require more attention. Formulation characteristics affecting microbicide efficacy include hydrophilicity, dispersibility, viscosity and bioadhesion. Development and standardization of human explant cultures and animal models to test the efficacy and safety of formulated compounds is essential. Pilot in vivo studies focusing on a thorough investigation of the changes in inflammatory cells and cytokines following topical application of candidate agents are recommended before the initiation of large-scale clinical trials.",

keywords = "HIV, Microbicides",

author = "Keller, {Marla J.} and Klotman, {Mary E.} and Herold, {Betsy C.}",

note = "Funding Information: We thank the Topical Prevention of Conception and Disease, Chicago, IL for SAMMA. This work was supported by Public Health Service Grants AI37940, HD41763 and HD 43733.",

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AU - Keller, Marla J.

AU - Klotman, Mary E.

AU - Herold, Betsy C.

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PY - 2003/5/1

Y1 - 2003/5/1

N2 - In summary, more extensive pre-clinical evaluation of SAMMA and other microbicides in development is required. The activity against primary isolates in the presence of genital tract fluids and over a broad pH range should be carefully evaluated. Optimization of formulations will require more attention. Formulation characteristics affecting microbicide efficacy include hydrophilicity, dispersibility, viscosity and bioadhesion. Development and standardization of human explant cultures and animal models to test the efficacy and safety of formulated compounds is essential. Pilot in vivo studies focusing on a thorough investigation of the changes in inflammatory cells and cytokines following topical application of candidate agents are recommended before the initiation of large-scale clinical trials.

AB - In summary, more extensive pre-clinical evaluation of SAMMA and other microbicides in development is required. The activity against primary isolates in the presence of genital tract fluids and over a broad pH range should be carefully evaluated. Optimization of formulations will require more attention. Formulation characteristics affecting microbicide efficacy include hydrophilicity, dispersibility, viscosity and bioadhesion. Development and standardization of human explant cultures and animal models to test the efficacy and safety of formulated compounds is essential. Pilot in vivo studies focusing on a thorough investigation of the changes in inflammatory cells and cytokines following topical application of candidate agents are recommended before the initiation of large-scale clinical trials.

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Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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