Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients

Clement E. Tagoe, Anna Zezon, Saakshi Khattri, Patricia Castellanos

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The aim of this study is to define the rheumatic manifestations of euthyroid patients with chronic lymphocytic thyroiditis (CLT) but without a well-defined connective tissue disease. Forty-six consecutive patients with anti-thyroid peroxidase (αTPO) and/or anti-thyroglobulin antibodies (αTG), and normal thyroid function in the absence of a well-defined connective tissue disease were included in a case-cohort study. Arthralgias were a presenting complaint in 98 % of patients. Fibromyalgia syndrome was found in 59 % of patients. Raynaud's phenomenon occurred in 28 % and sicca symptoms in 26 % of patients. Two patients had seronegative arthritis resembling rheumatoid arthritis. Arthritis was radiographically present in 88 %, affecting the spine in 45 % of patients. Thyroid-stimulating hormone (TSH) levels positively correlated with levels of αTPO, but not with erythrocyte sedimentation rate (ESR) or αTG levels. A positive ANA was found in 24 % of patients. One patient developed subclinical hypothyroidism during the study. Rheumatic manifestations frequently occur in patients with CLT in the absence of overt thyroid dysfunction and mimic the presentation of the well-defined connective tissue diseases.

Original languageEnglish (US)
Pages (from-to)1745-1752
Number of pages8
JournalRheumatology International
Issue number7
StatePublished - Jul 1 2013


  • Arthritis
  • Autoimmune thyroid disease
  • Chronic lymphocytic thyroiditis
  • Fibromyalgia
  • Hashimoto thyroiditis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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