Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Robert J. Levy; Joseph A. Sparano; Ghazali Khan

doi:10.1007/BF02990567

Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Robert J. Levy, Joseph A. Sparano, Ghazali Khan

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Medical Oncology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1007/BF02990567
State	Published - Dec 1995

Keywords

acute rhabdomyolysis
chemotherapy
cyclophosphamide
mitoxantrone
phosphorylase deficiency

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02990567

Cite this

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title = "Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy",

abstract = "Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.",

keywords = "acute rhabdomyolysis, chemotherapy, cyclophosphamide, mitoxantrone, phosphorylase deficiency",

author = "Levy, {Robert J.} and Sparano, {Joseph A.} and Ghazali Khan",

year = "1995",

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T2 - An unusual complication of cytotoxic chemotherapy

AU - Levy, Robert J.

AU - Sparano, Joseph A.

AU - Khan, Ghazali

PY - 1995/12

Y1 - 1995/12

N2 - Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

AB - Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

KW - acute rhabdomyolysis

KW - chemotherapy

KW - cyclophosphamide

KW - mitoxantrone

KW - phosphorylase deficiency

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IS - 4

ER -

Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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