Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Robert J. Levy; Joseph A. Sparano; Ghazali Khan

doi:10.1007/BF02990567

Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Robert J. Levy, Joseph A. Sparano, Ghazali Khan

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Medical Oncology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1007/BF02990567
State	Published - Dec 1 1995

Keywords

acute rhabdomyolysis
chemotherapy
cyclophosphamide
mitoxantrone
phosphorylase deficiency

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02990567

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abstract = "Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.",

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T2 - An unusual complication of cytotoxic chemotherapy

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AU - Sparano, Joseph A.

AU - Khan, Ghazali

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N2 - Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

AB - Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

KW - acute rhabdomyolysis

KW - chemotherapy

KW - cyclophosphamide

KW - mitoxantrone

KW - phosphorylase deficiency

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Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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