TY - JOUR
T1 - Review
T2 - Effect of drugs on human cough reflex sensitivity to inhaled capsaicin
AU - Dicpinigaitis, Peter V.
PY - 2012/11/12
Y1 - 2012/11/12
N2 - Capsaicin, the pungent extract of red peppers, has been used in clinical research for almost three decades. Capsaicin has gained favor as the provocative agent of choice to measure cough reflex sensitivity, as it induces cough in a safe, reproducible, and dose-dependent manner. One of the major uses of capsaicin cough challenge testing has been to evaluate the effect of a pharmacological intervention on the human cough reflex. The current review summarizes the published experience with capsaicin inhalation challenge in the evaluation of drug effects on cough reflex sensitivity. A notable contrast evident between studies demonstrating a drug effect (inhibition of cough reflex sensitivity) and those that do not, is the predominance of healthy volunteers as subjects in the latter. This observation suggests that subjects with pathological cough, rather than normal volunteers, comprise the optimal group in which to evaluate the effect of potential antitussive agents on human cough reflex sensitivity.
AB - Capsaicin, the pungent extract of red peppers, has been used in clinical research for almost three decades. Capsaicin has gained favor as the provocative agent of choice to measure cough reflex sensitivity, as it induces cough in a safe, reproducible, and dose-dependent manner. One of the major uses of capsaicin cough challenge testing has been to evaluate the effect of a pharmacological intervention on the human cough reflex. The current review summarizes the published experience with capsaicin inhalation challenge in the evaluation of drug effects on cough reflex sensitivity. A notable contrast evident between studies demonstrating a drug effect (inhibition of cough reflex sensitivity) and those that do not, is the predominance of healthy volunteers as subjects in the latter. This observation suggests that subjects with pathological cough, rather than normal volunteers, comprise the optimal group in which to evaluate the effect of potential antitussive agents on human cough reflex sensitivity.
KW - Antitussive
KW - Asthma
KW - Capsaicin
KW - Cough
KW - Respiratory tract infection
UR - http://www.scopus.com/inward/record.url?scp=84868649934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868649934&partnerID=8YFLogxK
U2 - 10.1186/1745-9974-8-10
DO - 10.1186/1745-9974-8-10
M3 - Review article
C2 - 23146824
AN - SCOPUS:84868649934
SN - 1745-9974
VL - 8
JO - Cough
JF - Cough
IS - 1
M1 - 10
ER -