Abstract
Leukoencephalopathy with stroke-like presentation (LEPS) is a rare complication of various chemotherapeutic agents, and it is associated with specific findings on diffusion-weighted MRI (DW-MRI). Herein, we report a case of LEPS in a patient treated with 5-fluorouracil (5-FU) who was found to be deficient in dihydropyrimidine dehydrogenase (DPD). • While the clinical syndrome of LEPS is well known, only limited DW-MRI data in LEPS after 5-FU exposure is presently available. The histopathological basis for these DW-MRI abnormalities may consist of vacuolation secondary to splitting of the myelin intraperiod line. • Early recognition of LEPS in 5-FU recipients is important to prevent irreversible neurologic damage from prolonged exposure. A comprehensive neuroimaging evaluation including DW-MRI is recommended to spare unnecessary and inappropriate invasive procedures or therapies.
Original language | English (US) |
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Pages (from-to) | 215-217 |
Number of pages | 3 |
Journal | Clinical colorectal cancer |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2012 |
Externally published | Yes |
Keywords
- 5-fluorouracil
- ADC
- DPD deficiency
- DWI
- Leukoencephalopathy
ASJC Scopus subject areas
- Oncology
- Gastroenterology