Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou; Oleg Gligich; Alvita C.Y. Chan; Diwakar Mohan; Uriel R. Felsen; Sabarish Ayyappan; Henny H. Billett; Edwin P. Hui; Anthony T. Chan; Radha Raghupathy

doi:10.1002/hon.2247

Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou, Oleg Gligich, Alvita C.Y. Chan, Diwakar Mohan, Uriel R. Felsen, Sabarish Ayyappan, Henny H. Billett, Edwin P. Hui, Anthony T. Chan, Radha Raghupathy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

Original language	English (US)
Pages (from-to)	64-68
Number of pages	5
Journal	Hematological Oncology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/hon.2247
State	Published - Mar 1 2017

Keywords

HIV
Hematological malignancy
Monoclonal proteins
Oligoclonal proteins
Paraproteins

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hon.2247

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title = "Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients",

abstract = "The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.",

keywords = "HIV, Hematological malignancy, Monoclonal proteins, Oligoclonal proteins, Paraproteins",

author = "Erin Jou and Oleg Gligich and Chan, {Alvita C.Y.} and Diwakar Mohan and Felsen, {Uriel R.} and Sabarish Ayyappan and Billett, {Henny H.} and Hui, {Edwin P.} and Chan, {Anthony T.} and Radha Raghupathy",

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year = "2017",

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doi = "10.1002/hon.2247",

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AU - Jou, Erin

AU - Gligich, Oleg

AU - Chan, Alvita C.Y.

AU - Mohan, Diwakar

AU - Felsen, Uriel R.

AU - Ayyappan, Sabarish

AU - Billett, Henny H.

AU - Hui, Edwin P.

AU - Chan, Anthony T.

AU - Raghupathy, Radha

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N2 - The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

AB - The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

KW - HIV

KW - Hematological malignancy

KW - Monoclonal proteins

KW - Oligoclonal proteins

KW - Paraproteins

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Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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