TY - JOUR
T1 - Restriction of enhanced [2-14C]deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats
AU - Ackermann, Robert F.
AU - Moshé, Solomon L.
AU - Albala, Bruce J.
N1 - Funding Information:
This work was supported by DOE Contract DE-AC03-76-SF00012, NIH Grants NS-15654 and NS-20253, and United Cerebral Palsy Associations Grant R-36986. The authors gratefully acknowledget he efforts of Mr. Wrother Meredith, whose technical expertise made collection of much of these data possible.
PY - 1989/4
Y1 - 1989/4
N2 - Sixteen-day-old albino rat pups were kindled to varying degrees of seizure severity with amygdala stimulations spaced 15 to 20 min apart. Subsequently, each rat pup was injected (ip) with 10 μCi of [2-14C]-deoxyglucose, and received several additional kindled seizures at regular intervals throughout the following 80 min, at which time it was killed and processed for deoxyglucose autoradiography. Increased seizure severity was associated with correspondingly increased deoxyglucose utilization in many rhinencephalic limbic structures. However, unlike adults, rat pups did not show discernibly increased neocortical, thalamic, or substantia nigra utilization. We postulate that the apparent confinement of seizure activity to limbic structures in pups is related to their relative lack of postictal seizure refractoriness, as well as to other indices of increased seizure susceptibility in immature animals.
AB - Sixteen-day-old albino rat pups were kindled to varying degrees of seizure severity with amygdala stimulations spaced 15 to 20 min apart. Subsequently, each rat pup was injected (ip) with 10 μCi of [2-14C]-deoxyglucose, and received several additional kindled seizures at regular intervals throughout the following 80 min, at which time it was killed and processed for deoxyglucose autoradiography. Increased seizure severity was associated with correspondingly increased deoxyglucose utilization in many rhinencephalic limbic structures. However, unlike adults, rat pups did not show discernibly increased neocortical, thalamic, or substantia nigra utilization. We postulate that the apparent confinement of seizure activity to limbic structures in pups is related to their relative lack of postictal seizure refractoriness, as well as to other indices of increased seizure susceptibility in immature animals.
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U2 - 10.1016/0014-4886(89)90011-3
DO - 10.1016/0014-4886(89)90011-3
M3 - Article
C2 - 2924873
AN - SCOPUS:0024542383
SN - 0014-4886
VL - 104
SP - 73
EP - 81
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -