REST, a master transcriptional regulator in neurodegenerative disease

Jee Yeon Hwang, R. Suzanne Zukin

Research output: Contribution to journalReview articlepeer-review

124 Scopus citations


The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and β-amyloid toxicity. This review focuses on recent findings that dysregulation of REST and REST-dependent epigenetic remodeling provide a central mechanism critical to the progressive neurodegeneration associated with neurologic disorders and diseases including global ischemia, stroke, epilepsy, Alzheimer's and Huntington's disease.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Neuroscience(all)


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