TY - JOUR
T1 - Respiratory and sleep patterns during nocturnal infusions of branched chain amino acids
AU - Kirvelä, O.
AU - Thorpy, M.
AU - Takala, J.
AU - Askanazi, J.
AU - Singer, P.
AU - Kvetan, V.
PY - 1990/11
Y1 - 1990/11
N2 - In the awake, normal subject, infusions of branched chain amino acids (BCAA) alter the ventilatory response to CO2. If this effect extends to the sleep state, it could contribute to our understanding of the neurophysiology of the sleep state as well as having clinical utility in ameliorating or preventing apnea syndromes. This study examined the effect of nocturnal BCAA infusions on sleep patterns (as measured by EEG, chest wall motion, Sao, and end‐tidal CO2) in five normal male subjects. Subjects were monitored with a polysomnograph from 21.00 to 7.00. Each subject was studied double‐blind in random order on three occasions: a) baseline, no infusion (B); b) control, with normal saline infusion (S); and c) treatment, infusion of BCAA (BCAA). Sleep pattern analysis did not demonstrate any measurable effect of the BCAA infusion. End‐tidal CO2 levels during BCAA infusion were lower than during baseline or control nights (meank ± s.d.; BCAA: 5.8 ± 0.7 kPa vs B: 6.9 ± 0.1 kPa, P< 0.01 and S: 6.7 ± 0.4 kPa, P< 0.05). This study demonstrates that nocturnal BCAA infusions have effects on respiratory control during sleep; further clinical studies are required to determine whether these data have implications for disease states.
AB - In the awake, normal subject, infusions of branched chain amino acids (BCAA) alter the ventilatory response to CO2. If this effect extends to the sleep state, it could contribute to our understanding of the neurophysiology of the sleep state as well as having clinical utility in ameliorating or preventing apnea syndromes. This study examined the effect of nocturnal BCAA infusions on sleep patterns (as measured by EEG, chest wall motion, Sao, and end‐tidal CO2) in five normal male subjects. Subjects were monitored with a polysomnograph from 21.00 to 7.00. Each subject was studied double‐blind in random order on three occasions: a) baseline, no infusion (B); b) control, with normal saline infusion (S); and c) treatment, infusion of BCAA (BCAA). Sleep pattern analysis did not demonstrate any measurable effect of the BCAA infusion. End‐tidal CO2 levels during BCAA infusion were lower than during baseline or control nights (meank ± s.d.; BCAA: 5.8 ± 0.7 kPa vs B: 6.9 ± 0.1 kPa, P< 0.01 and S: 6.7 ± 0.4 kPa, P< 0.05). This study demonstrates that nocturnal BCAA infusions have effects on respiratory control during sleep; further clinical studies are required to determine whether these data have implications for disease states.
KW - Arterial Paco
KW - REM‐sleep
KW - branched chain amino acids
KW - sleep apnea
KW - ventilation
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U2 - 10.1111/j.1399-6576.1990.tb03164.x
DO - 10.1111/j.1399-6576.1990.tb03164.x
M3 - Article
C2 - 2125794
AN - SCOPUS:0025202060
SN - 0001-5172
VL - 34
SP - 645
EP - 648
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
IS - 8
ER -