Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Kyoko Ito; Keisuke Ito

doi:10.1016/j.stem.2015.07.012

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Kyoko Ito
, Keisuke Ito

Cell Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Therapeutic targeting of pre-leukemic stem cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse. Now in Cell Stem Cell, Cai et al. (2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.

Original language	English (US)
Article number	1816
Pages (from-to)	129-131
Number of pages	3
Journal	Cell Stem Cell
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2015.07.012
State	Published - Aug 6 2015

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2015.07.012

Cite this

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title = "Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs",

abstract = "Therapeutic targeting of pre-leukemic stem cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse. Now in Cell Stem Cell, Cai et al. (2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.",

author = "Kyoko Ito and Keisuke Ito",

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AU - Ito, Keisuke

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AB - Therapeutic targeting of pre-leukemic stem cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse. Now in Cell Stem Cell, Cai et al. (2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.

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DO - 10.1016/j.stem.2015.07.012

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Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Abstract

ASJC Scopus subject areas

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