Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Ujjwal Neogi; Shwetha D. Rao; Irene Bontell; Jens Verheyen; Vasudev R. Rao; Sagar C. Gore; Neelesh Sonif; Anita Shet; Eugen Schülter; Maria L. Ekstrand; Amogne Wondwossen; Rolf Kaiser; Mallur S. Madhusudhan; Vinayaka R. Prasad; Anders Sonnerborg

doi:10.1097/QAD.0000000000000419

Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Ujjwal Neogi
, Shwetha D. Rao
, Irene Bontell
, Jens Verheyen
, Vasudev R. Rao
, Sagar C. Gore
, Neelesh Sonif
, Anita Shet
, Eugen Schülter
, Maria L. Ekstrand
, Amogne Wondwossen
, Rolf Kaiser
, Mallur S. Madhusudhan
, Vinayaka R. Prasad
, Anders Sonnerborg

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratioU17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Original language	English (US)
Pages (from-to)	2319-2322
Number of pages	4
Journal	AIDS
Volume	28
Issue number	15
DOIs	https://doi.org/10.1097/QAD.0000000000000419
State	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000000419

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Neogi, U., Rao, S. D., Bontell, I., Verheyen, J., Rao, V. R., Gore, S. C., Sonif, N., Shet, A., Schülter, E., Ekstrand, M. L., Wondwossen, A., Kaiser, R., Madhusudhan, M. S., Prasad, V. R., & Sonnerborg, A. (2014). Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. AIDS, 28(15), 2319-2322. https://doi.org/10.1097/QAD.0000000000000419

Neogi, U, Rao, SD, Bontell, I, Verheyen, J, Rao, VR, Gore, SC, Sonif, N, Shet, A, Schülter, E, Ekstrand, ML, Wondwossen, A, Kaiser, R, Madhusudhan, MS, Prasad, VR & Sonnerborg, A 2014, 'Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients', AIDS, vol. 28, no. 15, pp. 2319-2322. https://doi.org/10.1097/QAD.0000000000000419

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abstract = "A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratioU17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.",

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AU - Bontell, Irene

AU - Verheyen, Jens

AU - Rao, Vasudev R.

AU - Gore, Sagar C.

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AU - Schülter, Eugen

AU - Ekstrand, Maria L.

AU - Wondwossen, Amogne

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AU - Madhusudhan, Mallur S.

AU - Prasad, Vinayaka R.

AU - Sonnerborg, Anders

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Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Abstract

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