Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Ujjwal Neogi; Shwetha D. Rao; Irene Bontell; Jens Verheyen; Vasudev R. Rao; Sagar C. Gore; Neelesh Sonif; Anita Shet; Eugen Schülter; Maria L. Ekstrand; Amogne Wondwossen; Rolf Kaiser; Mallur S. Madhusudhan; Vinayaka R. Prasad; Anders Sonnerborg

doi:10.1097/QAD.0000000000000419

Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Ujjwal Neogi, Shwetha D. Rao, Irene Bontell, Jens Verheyen, Vasudev R. Rao, Sagar C. Gore, Neelesh Sonif, Anita Shet, Eugen Schülter, Maria L. Ekstrand, Amogne Wondwossen, Rolf Kaiser, Mallur S. Madhusudhan, Vinayaka R. Prasad, Anders Sonnerborg

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratioU17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Original language	English (US)
Pages (from-to)	2319-2322
Number of pages	4
Journal	AIDS
Volume	28
Issue number	15
DOIs	https://doi.org/10.1097/QAD.0000000000000419
State	Published - 2014

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAD.0000000000000419

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Neogi, U., Rao, S. D., Bontell, I., Verheyen, J., Rao, V. R., Gore, S. C., Sonif, N., Shet, A., Schülter, E., Ekstrand, M. L., Wondwossen, A., Kaiser, R., Madhusudhan, M. S., Prasad, V. R., & Sonnerborg, A. (2014). Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. AIDS, 28(15), 2319-2322. https://doi.org/10.1097/QAD.0000000000000419

Neogi, U, Rao, SD, Bontell, I, Verheyen, J, Rao, VR, Gore, SC, Sonif, N, Shet, A, Schülter, E, Ekstrand, ML, Wondwossen, A, Kaiser, R, Madhusudhan, MS, Prasad, VR & Sonnerborg, A 2014, 'Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients', AIDS, vol. 28, no. 15, pp. 2319-2322. https://doi.org/10.1097/QAD.0000000000000419

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AU - Bontell, Irene

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AU - Gore, Sagar C.

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Research letter: Novel tetra-peptide insertion in Gag-p6 ALIXbinding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients

Abstract

ASJC Scopus subject areas

UN SDGs

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