Requirement for prolactin during cell cycle regulated gene expression in cloned t-lymphocytes

Charles V. Clevenger, Amy L. Sillman, Joan Hanley-Hyde, Michael B. Prystowsky

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The neuroendocrine hormone PRL acts as a nase, cyclin B, and histone H3. Stimulation of L2 cells with progression factor during interleukin-2 (IL2) stimulated lym-PRL alone, however, induced only the expression of interferon phocyte proliferation. Since the sequential expression of cell regulatory factor-l. Depletion of PRL, through the use of an cycle regulated genes occurs during this process, we examined anti-PRL antiserum, inhibited IL2 driven proliferation and the the contribution of IL2 and PRL to specific RNA accumulation. expression of cyclin B and histone H3. These results demon-Stimulation of the cloned T cell line L2 with IL2 and PRL strate that PRL may regulate T cell proliferation by enhancing induced the sequential expression of interferon regulatory the expression of some genes necessary for entry into S-phase.

Original languageEnglish (US)
Pages (from-to)3216-3222
Number of pages7
Issue number6
StatePublished - Jun 1992
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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