Reproducibility of T and T2 quantification in a multi-vendor multi-site study

R. Lartey, A. Nanavati, J. Kim, M. Li, K. Xu, K. Nakamura, W. Shin, C. S. Winalski, N. Obuchowski, E. Bahroos, T. M. Link, P. A. Hardy, Q. Peng, K. Liu, M. Fung, C. Wu, X. Li

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To evaluate the multi-vendor multi-site reproducibility of two-dimensional (2D) multi-echo spin-echo (MESE) T2 mapping (product sequences); and to evaluate the longitudinal reproducibility of three-dimensional (3D) magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (MAPSS) T and T2 mapping (research sequences), and 2D MESE T2 mapping, separated by 6 months, in a multi-vendor multi-site setting. Methods: Phantoms and volunteers (n = 5 from each site, n = 20 in total) were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens, General Electric, and Phillips). Two traveling volunteers (3 knees) scanned at all 4 sites at baseline and 6-month follow-up. Data was transferred to one site for centralized processing. Coefficients of variation (CVs) were calculated to evaluate reproducibility. Results: For baseline 2D MESE T2 measures, average CV were 0.37–2.45% (intra-site) and 5.96% (inter-site) for phantoms, and 3.15–8.49% (intra-site) and 14.16% (inter-site) for volunteers. For longitudinal phantom data, intra-site CVs were 1.42–3.48% for 3D MAPSS T, 1.77–3.56% for 3D MAPSS T2, and 1.02–2.54% for 2D MESE T2. For the longitudinal volunteer data, the intra-site CVs were 2.60–4.86% for 3D MAPSS T, 3.33–7.25% for 3D MAPSS T2, and 3.11–8.77% for 2D MESE T2. Conclusion: This study demonstrated excellent intra-site reproducibility of 2D MESE T2 imaging, while its inter-site variation was slightly higher than 3D MAPSS T2 imaging (10.06% as previously reported). This study also showed excellent reproducibility of longitudinal T and T2 cartilage quantification, in a multi-vendor multi-site setting for both product 2D MESE T2 and 3D MAPSS T1p/T2 research sequences.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalOsteoarthritis and Cartilage
Issue number2
StatePublished - Feb 2023


  • Cartilage imaging
  • Magnetic resonance imaging
  • Repeatability
  • Reproducibility
  • T
  • T

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


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