Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Catharine I. Paules; Shannon K. Gallagher; Rekha R. Rapaka; Richard T. Davey; Sarah B. Doernberg; Robert Grossberg; Noreen A. Hynes; Philip O. Ponce; William R. Short; Jocelyn Voell; Jing Wang; Otto O. Yang; Cameron R. Wolfe; David C. Lye; Lori E. Dodd; Constance A. Benson

doi:10.1093/cid/ciab695

Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Catharine I. Paules
, Shannon K. Gallagher
, Rekha R. Rapaka
, Richard T. Davey
, Sarah B. Doernberg
, Robert Grossberg
, Noreen A. Hynes
, Philip O. Ponce
, William R. Short
, Jocelyn Voell
, Jing Wang
, Otto O. Yang
, Cameron R. Wolfe
, David C. Lye
, Lori E. Dodd
, Constance A. Benson

Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.

Original language	English (US)
Pages (from-to)	1260-1264
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	74
Issue number	7
DOIs	https://doi.org/10.1093/cid/ciab695
State	Published - Apr 1 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ACTT-1
COVID-19
remdesivir

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciab695

Cite this

Paules, C. I., Gallagher, S. K., Rapaka, R. R., Davey, R. T., Doernberg, S. B., Grossberg, R., Hynes, N. A., Ponce, P. O., Short, W. R., Voell, J., Wang, J., Yang, O. O., Wolfe, C. R., Lye, D. C., Dodd, L. E., & Benson, C. A. (2022). Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data. Clinical Infectious Diseases, 74(7), 1260-1264. https://doi.org/10.1093/cid/ciab695

Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data. / Paules, Catharine I.; Gallagher, Shannon K.; Rapaka, Rekha R. et al.
In: Clinical Infectious Diseases, Vol. 74, No. 7, 01.04.2022, p. 1260-1264.

Research output: Contribution to journal › Article › peer-review

Paules, CI, Gallagher, SK, Rapaka, RR, Davey, RT, Doernberg, SB, Grossberg, R, Hynes, NA, Ponce, PO, Short, WR, Voell, J, Wang, J, Yang, OO, Wolfe, CR, Lye, DC, Dodd, LE & Benson, CA 2022, 'Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data', Clinical Infectious Diseases, vol. 74, no. 7, pp. 1260-1264. https://doi.org/10.1093/cid/ciab695

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abstract = "This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.",

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Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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