Abstract
The history of the role of hematopoietic growth factors (HGFs) in the regulation of hematopoiesis is briefly reviewed, commencing with the studies that defined the hematopoietic stem cell and led to the development of in vitro assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the "permissive" versus "instructive" models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor-1 (CSF-1), is reviewed, including its function in development as revealed by studies of mouse mutants and its role in innate immunity, inflammatory disease and cancer.
| Original language | English (US) |
|---|---|
| Title of host publication | Stem Cells and their Potential for Clinical Application |
| Pages | 63-75 |
| Number of pages | 13 |
| State | Published - 2006 |
Publication series
| Name | NATO Security through Science Series B: Physics and Biophysics |
|---|---|
| ISSN (Print) | 1871-465X |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Blood cells
- CSF-1
- Macrophages
- Osteoclasts
- Review
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- Nuclear and High Energy Physics
- Physics and Astronomy (miscellaneous)
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