TY - JOUR
T1 - Recent advances and novel agents for gastrointestinal stromal tumor (GIST)
AU - Lamba, Gurpreet
AU - Ambrale, Samir
AU - Lee, Byung
AU - Gupta, Ridhi
AU - Rafiyath, Shamudheen M.
AU - Liu, Delong
PY - 2012
Y1 - 2012
N2 - The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic driver pathways, leading to dramatically improved clinical outcomes. A series of investigations and trials are underway to develop novel and effective ways to treat patients with GIST. In this review, we discuss the highlights of recent advances and novel agents for GIST therapy.
AB - The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic driver pathways, leading to dramatically improved clinical outcomes. A series of investigations and trials are underway to develop novel and effective ways to treat patients with GIST. In this review, we discuss the highlights of recent advances and novel agents for GIST therapy.
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U2 - 10.1186/1756-8722-5-21
DO - 10.1186/1756-8722-5-21
M3 - Review article
C2 - 22569033
AN - SCOPUS:84860631629
SN - 1756-8722
VL - 5
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
M1 - 21
ER -