TY - JOUR
T1 - Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma
AU - Lo Coco, Francesco
AU - Ye, Bihui H.
AU - Lista, Florigio
AU - Corradini, Paolo
AU - Offit, Kenneth
AU - Knowles, Daniel M.
AU - Chaganti, R. S.K.
AU - Dalla-Favera, Riccardo
PY - 1994/4/1
Y1 - 1994/4/1
N2 - The pathogenesis of non-Hodgkin's lymphoma (NHL) with a large cell component (DLLC, including diffuse large cell, DLCL; diffuse mixed cell, MX- D; and immunoblastic, IMB) is unknown. A novel candidate proto-oncogene, BCL6, that is involved in chromosome band 3q27 aberrations in NHL has been recently identified. We have investigated the incidence and disease- specificity of BCL6 rearrangements in a large panel of lymphoid tumors, including acute and chronic lymphoid leukemias (96 cases), various NHL types (125 cases), and multiple myelomas (23 cases). BCL6 rearrangements were found in 16/45 (35.5%) DLLC, more frequently in DLCL (15/33, 45%) than in MX-D (1/10, 10%), in 2/31 (6.4%) follicular NHL, and in no other tumor types. BCL6 rearrangements represent the first genetic lesion specifically and recurrently associated with DLLC and should prove useful for understanding the pathogenesis as well as for the clinical monitoring of these tumors.
AB - The pathogenesis of non-Hodgkin's lymphoma (NHL) with a large cell component (DLLC, including diffuse large cell, DLCL; diffuse mixed cell, MX- D; and immunoblastic, IMB) is unknown. A novel candidate proto-oncogene, BCL6, that is involved in chromosome band 3q27 aberrations in NHL has been recently identified. We have investigated the incidence and disease- specificity of BCL6 rearrangements in a large panel of lymphoid tumors, including acute and chronic lymphoid leukemias (96 cases), various NHL types (125 cases), and multiple myelomas (23 cases). BCL6 rearrangements were found in 16/45 (35.5%) DLLC, more frequently in DLCL (15/33, 45%) than in MX-D (1/10, 10%), in 2/31 (6.4%) follicular NHL, and in no other tumor types. BCL6 rearrangements represent the first genetic lesion specifically and recurrently associated with DLLC and should prove useful for understanding the pathogenesis as well as for the clinical monitoring of these tumors.
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U2 - 10.1182/blood.v83.7.1757.bloodjournal8371757
DO - 10.1182/blood.v83.7.1757.bloodjournal8371757
M3 - Article
C2 - 8142643
AN - SCOPUS:0028230387
SN - 0006-4971
VL - 83
SP - 1757
EP - 1759
JO - Blood
JF - Blood
IS - 7
ER -