Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis

Daniel Lorenzatti; Annalisa Filtz; Azeem Latib; Joseph DeRose; Damini Dey; Daniel S. Berman; Mario J. Garcia; Leandro Slipczuk

doi:10.1007/s10554-024-03216-6

Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis

Daniel Lorenzatti, Annalisa Filtz, Azeem Latib, Joseph DeRose, Damini Dey, Daniel S. Berman, Mario J. Garcia, Leandro Slipczuk

Research output: Contribution to journal › Article › peer-review

Abstract

We present a real-life case of a very young man with multiple risk factors who progressed rapidly from minimally obstructive non-calcified plaque on computed tomography angiography (CCTA) to severe three-vessel coronary disease presenting with STEMI. It questions the reliability of zero coronary calcium in high-risk subgroups like familial hypercholesterolemia, high Lp(a), and the young. While CCTA can accurately visualize non-calcified plaque, its interpretation requires expertise and clinical judgment should consider both imaging and clinical risk factors for management. Advanced plaque quantification, peri-coronary (PCAT), and epicardial (EAT) adipose tissue could help better-stratified patients but the evidence-based clinical application remains unknown.

Original language	English (US)
Pages (from-to)	2221-2225
Number of pages	5
Journal	International Journal of Cardiovascular Imaging
Volume	40
Issue number	10
DOIs	https://doi.org/10.1007/s10554-024-03216-6
State	Published - Oct 2024
Externally published	Yes

Keywords

CCTA
Coronary artery disease
FH
Familiar hypercholesterolemia
Plaque
Young

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s10554-024-03216-6

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title = "Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis",

abstract = "We present a real-life case of a very young man with multiple risk factors who progressed rapidly from minimally obstructive non-calcified plaque on computed tomography angiography (CCTA) to severe three-vessel coronary disease presenting with STEMI. It questions the reliability of zero coronary calcium in high-risk subgroups like familial hypercholesterolemia, high Lp(a), and the young. While CCTA can accurately visualize non-calcified plaque, its interpretation requires expertise and clinical judgment should consider both imaging and clinical risk factors for management. Advanced plaque quantification, peri-coronary (PCAT), and epicardial (EAT) adipose tissue could help better-stratified patients but the evidence-based clinical application remains unknown.",

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T2 - a retrospective advanced CCT phenotype analysis

AU - Lorenzatti, Daniel

AU - Filtz, Annalisa

AU - Latib, Azeem

AU - DeRose, Joseph

AU - Dey, Damini

AU - Berman, Daniel S.

AU - Garcia, Mario J.

AU - Slipczuk, Leandro

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/10

Y1 - 2024/10

N2 - We present a real-life case of a very young man with multiple risk factors who progressed rapidly from minimally obstructive non-calcified plaque on computed tomography angiography (CCTA) to severe three-vessel coronary disease presenting with STEMI. It questions the reliability of zero coronary calcium in high-risk subgroups like familial hypercholesterolemia, high Lp(a), and the young. While CCTA can accurately visualize non-calcified plaque, its interpretation requires expertise and clinical judgment should consider both imaging and clinical risk factors for management. Advanced plaque quantification, peri-coronary (PCAT), and epicardial (EAT) adipose tissue could help better-stratified patients but the evidence-based clinical application remains unknown.

AB - We present a real-life case of a very young man with multiple risk factors who progressed rapidly from minimally obstructive non-calcified plaque on computed tomography angiography (CCTA) to severe three-vessel coronary disease presenting with STEMI. It questions the reliability of zero coronary calcium in high-risk subgroups like familial hypercholesterolemia, high Lp(a), and the young. While CCTA can accurately visualize non-calcified plaque, its interpretation requires expertise and clinical judgment should consider both imaging and clinical risk factors for management. Advanced plaque quantification, peri-coronary (PCAT), and epicardial (EAT) adipose tissue could help better-stratified patients but the evidence-based clinical application remains unknown.

KW - CCTA

KW - Coronary artery disease

KW - FH

KW - Familiar hypercholesterolemia

KW - Plaque

KW - Young

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Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis

Abstract

Keywords

ASJC Scopus subject areas

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