TY - JOUR
T1 - Radioimmunotherapy of fungal diseases
T2 - The therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens
AU - Nosanchuk, Joshua D.
AU - Dadachova, Ekaterina
PY - 2012
Y1 - 2012
N2 - Radioimmunotherapy is the targeted delivery of cytocidal radiation to cells via specific antibody. Although mature for the treatment of cancer, RIT of infectious diseases is in preclinical development. However, as there is an obvious and urgent need for novel approaches to treat infectious diseases, RIT can provide us with a powerful approach to combat serious diseases, including invasive fungal infections. For example, RIT has proven more effective than standard amphotericin B for the treatment of experimental cryptococcosis. This review will discuss the concepts of RIT its applications for infectious diseases, and the strides made to date to bring RIT of infectious diseases to fruition. Finally, we will discuss the potential of PAN-FUNGAL RIT the targeting of conserved fungal cell surface antigens by RIT as a treatment modality for fungi prior to the formal microbiological identification of the specific pathogen. In sum, RIT provides a mechanism for the targeted killing of drug susceptible or resistant fungi irrespective of the host immune status and may dramatically reduce the length of therapy currently required for many invasive fungal diseases.
AB - Radioimmunotherapy is the targeted delivery of cytocidal radiation to cells via specific antibody. Although mature for the treatment of cancer, RIT of infectious diseases is in preclinical development. However, as there is an obvious and urgent need for novel approaches to treat infectious diseases, RIT can provide us with a powerful approach to combat serious diseases, including invasive fungal infections. For example, RIT has proven more effective than standard amphotericin B for the treatment of experimental cryptococcosis. This review will discuss the concepts of RIT its applications for infectious diseases, and the strides made to date to bring RIT of infectious diseases to fruition. Finally, we will discuss the potential of PAN-FUNGAL RIT the targeting of conserved fungal cell surface antigens by RIT as a treatment modality for fungi prior to the formal microbiological identification of the specific pathogen. In sum, RIT provides a mechanism for the targeted killing of drug susceptible or resistant fungi irrespective of the host immune status and may dramatically reduce the length of therapy currently required for many invasive fungal diseases.
KW - Antibody
KW - Beta-glucan
KW - Candida albicans
KW - Cryptococcus neoformans
KW - Heat shock protein 60
KW - Histoplasma capsulatum
KW - Melanin
UR - http://www.scopus.com/inward/record.url?scp=84875773694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875773694&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2011.00283
DO - 10.3389/fmicb.2011.00283
M3 - Review article
C2 - 22275913
AN - SCOPUS:84875773694
SN - 1664-302X
VL - 2
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - JAN
ER -
