TY - JOUR
T1 - Radiation-induced tumors in irradiated stage I testicular seminoma
T2 - Results of a 25-year follow-up (1968-1993)
AU - Stein, Moshe E.
AU - Leviov, Michelle
AU - Drumea, Keren
AU - Moshkovitz, Boaz
AU - Nativ, Ofer
AU - Milstein, David
AU - Sabo, Edmond
AU - Kuten, Abraham
PY - 1998/1
Y1 - 1998/1
N2 - Background and Objectives: Testicular seminoma is a very radiosensitive and curable cancer, with survival rates following radiation therapy within the range of 90-98% without apparent severe side effects. However, long-term survival following exposure to moderate-dose radiation therapy can result in radiation-induced tumors. Methods: The incidence of radiation-induced tumors was determined in 81 irradiated stage I testicular seminoma patients treated at the Northern Israel Oncology Center (NIOC) from 1968 through 1993. Results: Three (4%) patients developed second cancers within the high-dose volume. Indeed, those patients received a higher than usual dose to the para- aortic and pelvic regions. One patient, who developed inoperable pancreatic carcinoma, was treated with 'hockey stick' field and mediastinal irradiation, plus, as a result of relapses, multiple cisplatin and VP-16 based regimens. Conclusions: The elimination of causative factors through lower total doses and field size reduction may reduce the, albeit very low, incidence of radiation-induced cancer in cured testicular seminoma.
AB - Background and Objectives: Testicular seminoma is a very radiosensitive and curable cancer, with survival rates following radiation therapy within the range of 90-98% without apparent severe side effects. However, long-term survival following exposure to moderate-dose radiation therapy can result in radiation-induced tumors. Methods: The incidence of radiation-induced tumors was determined in 81 irradiated stage I testicular seminoma patients treated at the Northern Israel Oncology Center (NIOC) from 1968 through 1993. Results: Three (4%) patients developed second cancers within the high-dose volume. Indeed, those patients received a higher than usual dose to the para- aortic and pelvic regions. One patient, who developed inoperable pancreatic carcinoma, was treated with 'hockey stick' field and mediastinal irradiation, plus, as a result of relapses, multiple cisplatin and VP-16 based regimens. Conclusions: The elimination of causative factors through lower total doses and field size reduction may reduce the, albeit very low, incidence of radiation-induced cancer in cured testicular seminoma.
KW - Induced tumors
KW - Radiotherapy
KW - Stage I
KW - Testicular seminoma
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U2 - 10.1002/(SICI)1096-9098(199801)67:1<38::AID-JSO8>3.0.CO;2-N
DO - 10.1002/(SICI)1096-9098(199801)67:1<38::AID-JSO8>3.0.CO;2-N
M3 - Article
C2 - 9457255
AN - SCOPUS:0031906428
SN - 0022-4790
VL - 67
SP - 38
EP - 40
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 1
ER -