TY - JOUR
T1 - Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex
AU - Rubinstein, Arye
AU - Morecki, Rachel
AU - Silverman, Bernard
AU - Charytan, Morris
AU - Krieger, Ben Zion
AU - Andiman, Warren
AU - Ziprkowski, Micha N.
AU - Goldman, Harold
N1 - Funding Information:
Supported by Grants AI 20671, A1 22300-01, AI 21186, and AI 14741 from the National Institutes of Health. Submitted for publication Feb. 26, 1985; accepted Oct. 16, t985. Reprint requests: Rachel Morecki, M.D., Department of Pathology, Albert Einstein College of Medicine, Forchheimer Building, Rm. 532, 1300 Morris Park Ave., Bronx, NY 10461.
PY - 1986/4
Y1 - 1986/4
N2 - Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.
AB - Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.
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U2 - 10.1016/S0022-3476(86)80822-8
DO - 10.1016/S0022-3476(86)80822-8
M3 - Article
C2 - 3007714
AN - SCOPUS:0022642472
SN - 0022-3476
VL - 108
SP - 498
EP - 503
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -
