Protein kinase D: Coupling extracellular stimuli to the regulation of cell physiology

Ya Fu; Charles S. Rubin

doi:10.1038/embor.2011.139

Protein kinase D: Coupling extracellular stimuli to the regulation of cell physiology

Ya Fu, Charles S. Rubin

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans- and autophosphorylation, as well as the subcellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.

Original language	English (US)
Pages (from-to)	785-796
Number of pages	12
Journal	EMBO Reports
Volume	12
Issue number	8
DOIs	https://doi.org/10.1038/embor.2011.139
State	Published - Aug 2011
Externally published	Yes

Keywords

PKD effectors
PKD functions
PKD inhibitors
PKD regulation
diacylglycerol
protein kinase D

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/embor.2011.139

Cite this

@article{bee6ea13dc6d48b7bcac3900ffbe174b,

title = "Protein kinase D: Coupling extracellular stimuli to the regulation of cell physiology",

abstract = "Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans- and autophosphorylation, as well as the subcellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.",

keywords = "PKD effectors, PKD functions, PKD inhibitors, PKD regulation, diacylglycerol, protein kinase D",

author = "Ya Fu and Rubin, {Charles S.}",

year = "2011",

month = aug,

doi = "10.1038/embor.2011.139",

language = "English (US)",

volume = "12",

pages = "785--796",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "Nature Publishing Group",

number = "8",

}

TY - JOUR

T1 - Protein kinase D

T2 - Coupling extracellular stimuli to the regulation of cell physiology

AU - Fu, Ya

AU - Rubin, Charles S.

PY - 2011/8

Y1 - 2011/8

N2 - Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans- and autophosphorylation, as well as the subcellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.

AB - Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG) biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized transport of Golgi vesicles, as well as cell migration and survival after oxidative stress, PKDs substantially expand the range of physiological processes controlled by DAG. Dysregulated PKDs have been linked to pathologies including heart hypertrophy and cancer invasiveness. Our understanding of PKD regulation by trans- and autophosphorylation, as well as the subcellular dynamics of PKD substrate phosphorylation, have increased markedly. Selective PKD inhibitors provide new, powerful tools for elucidating the physiological roles of PKDs and potentially treating cardiac disease and cancer.

KW - PKD effectors

KW - PKD functions

KW - PKD inhibitors

KW - PKD regulation

KW - diacylglycerol

KW - protein kinase D

UR - http://www.scopus.com/inward/record.url?scp=79961026124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961026124&partnerID=8YFLogxK

U2 - 10.1038/embor.2011.139

DO - 10.1038/embor.2011.139

M3 - Review article

C2 - 21738220

AN - SCOPUS:79961026124

SN - 1469-221X

VL - 12

SP - 785

EP - 796

JO - EMBO Reports

JF - EMBO Reports

IS - 8

ER -

Protein kinase D: Coupling extracellular stimuli to the regulation of cell physiology

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this