Prolonged gonadotropin stimulation is associated with decreased ART success

Meleen Chuang, Athena Zapantis, Martina Taylor, Sangita K. Jindal, Genevieve S. Neal-Perry, Harry J. Lieman, Alex Joel Polotsky

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Purpose: To evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART. Methods: All IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed. Results: Out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis. Conclusions: Prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Issue number12
StatePublished - Dec 2010


  • Assisted reproduction
  • Gonadotropins
  • IVF/ICSI outcome
  • Infertility
  • Ovarian stimulation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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