Prolactin as a Second Messenger for Interleukin 2

Michael B. Prystowsky, Charles V. Clevenger

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The generation of an effective immune response requires the selection and proliferation of antigen-specific lymphocytes. Activation of at least some T lymphocytes involves the sequential stimulation of cell surface receptors, including the T-cell receptor for antigen, the interleukin 2 receptor, and the prolactin receptor. Prolactin signaling in T lymphocytes appears to utilize a classical receptor-mediated kinase cascade and a novel peptide hormone activation pathway involving nuclear translocation.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
Issue number1
StatePublished - Aug 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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