Primary Central Nervous System Lymphomas

Jerome J. Graber, Antonio M.P. Omuro

Research output: Chapter in Book/Report/Conference proceedingChapter


Primary CNS lymphoma (PCNSL) is a non-Hodgkin lymphoma that may develop in both immunocompetent and immunosuppressed patients. Early suspicion based on imaging characteristics may improve diagnostic accuracy, avoid inappropriate interventions, and expedite appropriate therapy. Treatment with high dose methotrexate-based chemotherapy, with or without radiotherapy, may result in long-term survival in up to 25% of patients. However, the optimal regimen remains to be determined, and disease relapses and treatment-related CNS neurotoxicity remain common.

Original languageEnglish (US)
Title of host publicationNeuro-oncology
Subtitle of host publicationFirst Edition
PublisherBlackwell Publishing Ltd
Number of pages9
ISBN (Print)9780470655757
StatePublished - Feb 29 2012


  • Methotrexate
  • Ocular lymphoma
  • Primary central nervous system lymphoma

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine


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