Prevalence of atrial fibrillation and procedural outcome in patients undergoing catheter ablation for premature ventricular complexes

Fengwei Zou, Luigi Di Biase, Sanghamitra Mohanty, Xiaodong Zhang, Sai Shishir Shetty, Carola Gianni, Domenico G. Della Rocca, Aung Lin, Roberto Arosio, Marco Schiavone, Giovanni Forleo, Angel Mayedo, Bryan MacDonald, Amin Al-Ahmad, Mohamed Bassiouny, G. Joseph Gallinghouse, Rodney Horton, John D. Burkhardt, Andrea Natale

Research output: Contribution to journalArticlepeer-review


Introduction: Atrial fibrillation (AF) and premature ventricular complexes (PVC) are common arrhythmias. We aimed to investigate AF prevalence in patients with PVC and its impact on PVC ablation outcomes. Methods: Consecutive patients undergoing PVC ablation at a single institution between 2016 and 2019 were included and prospectively followed for 2 years. Patients with severe valvular heart disease, hyperthyroidism, malignancy, alcohol use disorder and advanced renal/hepatic diseases were excluded. Twelve-lead electrocardiograms were used to diagnose AF and assess PVC morphology. All PVCs were targeted for ablation using 4-mm irrigated-tip catheters at standardized radiofrequency power guided by 3-D mapping and intracardiac echocardiography. Patients were followed with remote monitoring, device interrogations and office visits every 6 months for 2 years. Detection of any PVCs in follow-up was considered as recurrence. Results: A total of 394 patients underwent PVC ablation and 96 (24%) had concurrent AF. Patients with PVC and AF were significantly older (68.2 ± 10.8 vs. 58.3 ± 15.8 years, p <.001), had lower LV ejection fraction (43.3 ± 13.3% vs. 49.6 ± 12.4%, p <.001), higher CHA2DS2-VASc (2.8 ± 1.3 vs. 2.0 ± 1.3, p <.001) than those without. PVCs with ≥2 morphologies were detected in 60.4% and 13.7% patients with vs without AF (p <.001). At 2-year follow-up, PVC recurrence rate was significantly higher in patients with vs without AF (17.7% vs. 9.4%, p =.02). Conclusion: AF was documented in 1/4 of patients undergoing PVC ablation and was associated with lower procedural success at long-term follow-up. This was likely attributed to older age, worse LV function and higher prevalence of multiple PVC morphologies in patients with concurrent AF.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of cardiovascular electrophysiology
Issue number1
StatePublished - Jan 2023


  • atrial fibrillation
  • catheter ablation
  • premature ventricular complex
  • premature ventricular complex recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Prevalence of atrial fibrillation and procedural outcome in patients undergoing catheter ablation for premature ventricular complexes'. Together they form a unique fingerprint.

Cite this