Preterm rabbit model of glycerol-induced intraventricular hemorrhage

Research output: Chapter in Book/Report/Conference proceedingChapter


Intraventricular hemorrhage (IVH) remains a major complication of prematurity. We have developed a model of IVH in preterm rabbit pups. We deliver rabbit pups prematurely by C-section at 29-day gestational age (term = 32 days) and inject intraperitoneal glycerol at 3 h age to induce IVH. About 80 % of glycerol-treated pups develop IVH within 8 h age, which can be detected accurately with head ultrasound. These pups are reared in an infant incubator and gavage fed. At postnatal day 14, they exhibit hypomyelination, gliosis, and impaired neurological function. Hence, this is a novel animal model of IVH that can be used to test strategies to prevent post-hemorrhagic complication of IVH.

Original languageEnglish (US)
Title of host publicationAnimal Models of Neurodevelopmental Disorders
PublisherSpringer New York
Number of pages10
ISBN (Electronic)9781493927098
ISBN (Print)9781493927081
StatePublished - Sep 19 2015
Externally publishedYes


  • Germinal matrix
  • Gliosis
  • Glycerol
  • Head ultrasound
  • Hypomyelination
  • Intraventricular hemorrhage

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology


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