Presynapses go nuclear!

Dana O. Kravchick, Bryen A. Jordan

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations


Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression. Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds us that presynaptic zones should not be ignored when considering synapse-to-nucleus signaling. Synaptic signaling altering nuclear gene expression and long-term changes in synapse function occurs not only on postsynaptic, but also on presynaptic sites.

Original languageEnglish (US)
Pages (from-to)984-986
Number of pages3
JournalEMBO Journal
Issue number8
StatePublished - Apr 15 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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