Preparation of 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 as a potential antimalarial agent

E. Dadachova

doi:10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O

Preparation of ¹⁹⁸Au(I)-labelled gold-chloroquine complex [¹⁹⁸Au(PPh₃)(CQ)]PF₆ as a potential antimalarial agent

E. Dadachova

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

¹⁹⁸Au(I)-labelled gold-chloroquine complex [¹⁹⁸Au(PPh₃)(CQ)]PF₆ has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh₃)(CQ)]PF₆. [¹⁹⁸Au(PPh₃)(CQ)]PF₆ was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

Original language	English (US)
Pages (from-to)	287-292
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O
State	Published - 1999
Externally published	Yes

Keywords

Au
Chloroquine-resistance
Malaria
Radioisotopes
Radiotherapy
[Au(PPh)(CQ)]PF x 2HO

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O

Cite this

@article{5b371ea945b54ceb835b77e1d7afce17,

title = "Preparation of 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 as a potential antimalarial agent",

abstract = "198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak{\textregistered} C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.",

keywords = "Au, Chloroquine-resistance, Malaria, Radioisotopes, Radiotherapy, [Au(PPh)(CQ)]PF x 2HO",

author = "E. Dadachova",

year = "1999",

doi = "10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O",

language = "English (US)",

volume = "42",

pages = "287--292",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Preparation of 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 as a potential antimalarial agent

AU - Dadachova, E.

PY - 1999

Y1 - 1999

N2 - 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

AB - 198Au(I)-labelled gold-chloroquine complex [198Au(PPh3)(CQ)]PF6 has been prepared for the enhancement of antimalarial action against chloroquine-resistant strains of Plasmodium falciparum of recently reported [Au(PPh3)(CQ)]PF6. [198Au(PPh3)(CQ)]PF6 was synthesized via 3-step route starting with irradiated in the reactor for 2 hours Au foil and purified on Sep-Pak® C18 cartridge. Specific activity of the complex was 1.5 mCi/mg. The possibility of using metal complexes radiolabelled with therapeutic radioisotopes for treatment of chloroquine-resistant malaria is discussed.

KW - Au

KW - Chloroquine-resistance

KW - Malaria

KW - Radioisotopes

KW - Radiotherapy

KW - [Au(PPh)(CQ)]PF x 2HO

UR - http://www.scopus.com/inward/record.url?scp=0032983028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032983028&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O

DO - 10.1002/(SICI)1099-1344(199903)42:3<287::AID-JLCR189>3.0.CO;2-O

M3 - Article

AN - SCOPUS:0032983028

SN - 0362-4803

VL - 42

SP - 287

EP - 292

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 3

ER -