Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation

Hiroki Nariai, Dana E. Price, Ajit Jada, Lauren Weintraub, Karen M. Weidenheim, William A. Gomes, Adam S. Levy, Rick Abbott, Fatema Malbari

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalFetal and Pediatric Pathology
Issue number4
StatePublished - Apr 26 2016


  • Congenital brain tumor
  • Immature teratoma
  • MIB1/Ki-67 proliferation index
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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