Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation

Hiroki Nariai; Dana E. Price; Ajit Jada; Lauren Weintraub; Karen M. Weidenheim; William A. Gomes; Adam S. Levy; Rick Abbott; Fatema Malbari

doi:10.3109/15513815.2016.1172687

Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation

Hiroki Nariai, Dana E. Price, Ajit Jada, Lauren Weintraub, Karen M. Weidenheim, William A. Gomes, Adam S. Levy, Rick Abbott, Fatema Malbari

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

Original language	English (US)
Pages (from-to)	260-264
Number of pages	5
Journal	Fetal and Pediatric Pathology
Volume	35
Issue number	4
DOIs	https://doi.org/10.3109/15513815.2016.1172687
State	Published - Apr 26 2016

Keywords

Congenital brain tumor
Immature teratoma
MIB1/Ki-67 proliferation index
Prenatal diagnosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.3109/15513815.2016.1172687

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title = "Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation",

abstract = "Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.",

keywords = "Congenital brain tumor, Immature teratoma, MIB1/Ki-67 proliferation index, Prenatal diagnosis",

author = "Hiroki Nariai and Price, {Dana E.} and Ajit Jada and Lauren Weintraub and Weidenheim, {Karen M.} and Gomes, {William A.} and Levy, {Adam S.} and Rick Abbott and Fatema Malbari",

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year = "2016",

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day = "26",

doi = "10.3109/15513815.2016.1172687",

language = "English (US)",

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T1 - Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation

AU - Nariai, Hiroki

AU - Price, Dana E.

AU - Jada, Ajit

AU - Weintraub, Lauren

AU - Weidenheim, Karen M.

AU - Gomes, William A.

AU - Levy, Adam S.

AU - Abbott, Rick

AU - Malbari, Fatema

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

AB - Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.

KW - Congenital brain tumor

KW - Immature teratoma

KW - MIB1/Ki-67 proliferation index

KW - Prenatal diagnosis

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Prenatally diagnosed aggressive intracranial immature teratoma–Clinicopathological correlation

Abstract

Keywords

ASJC Scopus subject areas

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