Prefrontal and midline interactions mediating behavioural control

Catherine Fassbender, Robert Hester, Kevin Murphy, John J. Foxe, Deirdre M. Foxe, Hugh Garavan

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Top-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalEuropean Journal of Neuroscience
Issue number1
StatePublished - Jan 2009
Externally publishedYes


  • Anterior cingulate cortex
  • Cognitive control
  • Dorsolateral prefrontal cortex
  • Human
  • Pre-supplementary motor area
  • fMRI

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Prefrontal and midline interactions mediating behavioural control'. Together they form a unique fingerprint.

Cite this