Predictors of successful closure of patent ductus arteriosus with indomethacin

M. F. Ahamed, P. Verma, S. Lee, M. Vega, D. Wang, M. Kim, M. Fuloria

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective:To determine whether platelet counts can predict the likelihood of successful closure of patent ductus arteriosus (PDA) with indomethacin.Study Design:This was a retrospective cohort study of infants <32 weeks' gestational age (GA) and birth weight <1500 g with PDA. Clinical characteristics between infants who achieved ductal closure with indomethacin and those who failed were compared. Multivariable logistic regression was used to identify predictors of successful ductal closure.Results:In infants with hemodynamically significant PDA, older GA (odds ratio=1.54; 95% confidence interval: 1.12 to 2.13), male gender (odds ratio=3.02; 95% confidence interval: 1.08 to 8.49) and higher platelet count (odds ratio=1.5; 95% confidence interval: 1.04 to 2.17) prior to indomethacin treatment were associated with successful ductal closure with indomethacin.Conclusion:Older GA, male gender and higher platelet count at time of treatment of hemodynamically significant PDA are predictors of successful ductal closure with indomethacin.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalJournal of Perinatology
Issue number9
StatePublished - Sep 28 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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