PRC1 preserves epidermal tissue integrity independently of PRC2

Idan Cohen; Dejian Zhao; Gopinathan Menon; Manabu Nakayama; Haruhiko Koseki; Deyou Zheng; Elena Ezhkova

doi:10.1101/gad.319939.118

PRC1 preserves epidermal tissue integrity independently of PRC2

Idan Cohen, Dejian Zhao, Gopinathan Menon, Manabu Nakayama, Haruhiko Koseki, Deyou Zheng, Elena Ezhkova

Neurology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.

Original language	English (US)
Pages (from-to)	55-60
Number of pages	6
Journal	Genes and Development
Volume	33
Issue number	1-2
DOIs	https://doi.org/10.1101/gad.319939.118
State	Published - Jan 1 2019

Keywords

Cell adhesion
Epidermis
Epigenetics
PRC1
PRC2
Polycomb complex
Skin

ASJC Scopus subject areas

Genetics
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/gad.319939.118

Cite this

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title = "PRC1 preserves epidermal tissue integrity independently of PRC2",

abstract = "Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.",

keywords = "Cell adhesion, Epidermis, Epigenetics, PRC1, PRC2, Polycomb complex, Skin",

author = "Idan Cohen and Dejian Zhao and Gopinathan Menon and Manabu Nakayama and Haruhiko Koseki and Deyou Zheng and Elena Ezhkova",

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AU - Cohen, Idan

AU - Zhao, Dejian

AU - Menon, Gopinathan

AU - Nakayama, Manabu

AU - Koseki, Haruhiko

AU - Zheng, Deyou

AU - Ezhkova, Elena

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.

AB - Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.

KW - Cell adhesion

KW - Epidermis

KW - Epigenetics

KW - PRC1

KW - PRC2

KW - Polycomb complex

KW - Skin

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PRC1 preserves epidermal tissue integrity independently of PRC2

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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