Postoperative Infection Rate and Associated Factors Following Endoscopic Sinus Surgery

Sharan J. Shah, Vivian S. Hawn, Nina Zhu, Christina H. Fang, Qi Gao, Nadeem A. Akbar, Waleed M. Abuzeid

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: There is a paucity of data on postoperative infections after endoscopic sinus surgery and associated risk factors. Our objective was to evaluate a cohort of patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis to determine which perioperative factors may be associated with infection in the 30-day postoperative period. Methods: A retrospective cohort study of adults who underwent ESS at a tertiary academic medical center from 2015 to 2018 was performed. The primary outcome was incidence of postoperative infection, defined by identification of sinus purulence on nasal endoscopy necessitating antibiotics within 30 days of surgery. Independent variables collated included the result of postoperative cultures and use of perioperative antibiotics, oral corticosteroids, packing, and steroid-eluting stents. Statistical analysis involved bivariate analysis to identify variables that correlated with postoperative infection and subsequent multivariate logistic regression to identify independent risk factors. Results: Three hundred seventy-eight unique ESS cases performed in 356 patients were reviewed. The mean age was 46 years (range, 18-87). The most common indication for surgery was chronic rhinosinusitis without nasal polyposis. The postoperative infection rate was 10.1%. The most commonly cultured pathogen was Staphylococcus aureus. Multivariate logistic regression analysis showed that postoperative systemic corticosteroid use was the only risk factor independently associated with infection (OR 3.47 [95% CI 1.23-9.76], P =.018). Conclusion: The incidence of postoperative infection following ESS was 10.1%. The use of postoperative systemic corticosteroids independently increased the risk of infection by 3.47-fold.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Issue number1
StatePublished - Jan 2022


  • paranasal sinus disease
  • postoperative complications
  • postoperative period
  • sinusitis
  • steroids
  • surgical wound infection

ASJC Scopus subject areas

  • Otorhinolaryngology


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