TY - JOUR
T1 - Post-translational modifications in MeHg-induced neurotoxicity
AU - Ke, Tao
AU - Gonçalves, Filipe Marques
AU - Gonçalves, Cinara Ludvig
AU - dos Santos, Alessandra Antunes
AU - Rocha, João B.T.
AU - Farina, Marcelo
AU - Skalny, Anatoly
AU - Tsatsakis, Aristidis
AU - Bowman, Aaron B.
AU - Aschner, Michael
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been extensively investigated especially because of their congenital effects. In this context, studies on the molecular mechanism of MeHg-induced neurotoxicity are pivotal to the understanding of its toxic effects and the development of preventive measures. Post-translational modifications (PTMs) of proteins, such as phosphorylation, ubiquitination, and acetylation are essential for the proper function of proteins and play important roles in the regulation of cellular homeostasis. The rapid and transient nature of many PTMs allows efficient signal transduction in response to stress. This review summarizes the current knowledge of PTMs in MeHg-induced neurotoxicity, including the most commonly PTMs, as well as PTMs induced by oxidative stress and PTMs of antioxidant proteins. Though PTMs represent an important molecular mechanism for maintaining cellular homeostasis and are involved in the neurotoxic effects of MeHg, we are far from understanding the complete picture on their role, and further research is warranted to increase our knowledge of PTMs in MeHg-induced neurotoxicity.
AB - Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been extensively investigated especially because of their congenital effects. In this context, studies on the molecular mechanism of MeHg-induced neurotoxicity are pivotal to the understanding of its toxic effects and the development of preventive measures. Post-translational modifications (PTMs) of proteins, such as phosphorylation, ubiquitination, and acetylation are essential for the proper function of proteins and play important roles in the regulation of cellular homeostasis. The rapid and transient nature of many PTMs allows efficient signal transduction in response to stress. This review summarizes the current knowledge of PTMs in MeHg-induced neurotoxicity, including the most commonly PTMs, as well as PTMs induced by oxidative stress and PTMs of antioxidant proteins. Though PTMs represent an important molecular mechanism for maintaining cellular homeostasis and are involved in the neurotoxic effects of MeHg, we are far from understanding the complete picture on their role, and further research is warranted to increase our knowledge of PTMs in MeHg-induced neurotoxicity.
KW - Methylmercury
KW - Neurotoxicity
KW - Post-translational modification
UR - http://www.scopus.com/inward/record.url?scp=85056567543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056567543&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2018.10.024
DO - 10.1016/j.bbadis.2018.10.024
M3 - Review article
C2 - 30385410
AN - SCOPUS:85056567543
SN - 0925-4439
VL - 1865
SP - 2068
EP - 2081
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 8
ER -
