TY - JOUR
T1 - Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population
AU - Liu, Jixia
AU - Shi, Yongyong
AU - Tang, Wei
AU - Guo, Tingwei
AU - Li, Dawei
AU - Yang, Yifeng
AU - Zhao, Xinzhi
AU - Wang, Hongsheng
AU - Li, Xingwang
AU - Feng, Guoyin
AU - Gu, Niufan
AU - Zhu, Shaomin
AU - Liu, Huijun
AU - Guo, Yangling
AU - Shi, Jianguo
AU - Sang, Hong
AU - Yan, Lijuan
AU - He, Lin
N1 - Funding Information:
We are grateful to all the participants as well as the psychiatrists and mental health workers working on this project. This work was supported by grants from the Ministry of Education, PRC, the national 973 and 863 Programs of China, the National Natural Science Foundation of China, and the Shanghai Municipal Commission for Science and Technology.
PY - 2005/9/2
Y1 - 2005/9/2
N2 - A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global p = 0.00157-0.00588) which had not been identified in Lo's study. Our data indicated that the haplotype 'GACTCT' (p = 0.00215, frequency = 53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.
AB - A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global p = 0.00157-0.00588) which had not been identified in Lo's study. Our data indicated that the haplotype 'GACTCT' (p = 0.00215, frequency = 53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.
KW - Association
KW - GABAergic neurotransmission system
KW - GABRB2
KW - Haplotype
KW - Transmission disequilibrium
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U2 - 10.1016/j.bbrc.2005.06.167
DO - 10.1016/j.bbrc.2005.06.167
M3 - Article
C2 - 16023997
AN - SCOPUS:22744456295
SN - 0006-291X
VL - 334
SP - 817
EP - 823
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -