Porphyrins in Dubin-Johnson Syndrome

L. James Strand, Allan W. Wolkoff, Irwin M. Arias

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: I have some questions and comments about the article by Wolkoff et al. entitled “Inheritance of the Dubin-Johnson Syndrome” (N Engl J Med 288:113, 1973). The authors, and others previously, have observed both decreased urinary excretion of coproporphyrin III and increased excretion of coproporphyrin I in the Dubin-Johnson syndrome, yielding an abnormally high ratio of I-isomer excretion. The “obligate heterozygotes” do not conform to this pattern in that decreased III-isomer excretion is not associated with increased I-isomer excretion to yield only a 7 per cent increase in percentage of coproporphyrin I excretion vs. controls. Although the authors.

Original languageEnglish (US)
Pages (from-to)795-796
Number of pages2
JournalNew England Journal of Medicine
Issue number15
StatePublished - Apr 12 1973

ASJC Scopus subject areas

  • Medicine(all)


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