@article{60648e2330bf4836b5cdd10f9f59a57b,
title = "Polygenic risk for depression increases risk of ischemic stroke: From the stroke genetics network study",
abstract = "Background and Purpose - Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis. Methods - We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association study of ischemic stroke in the Stroke Genetics Network of National Institute of Neurological Disorders and Stroke. Included in separate analyses were 12 577 stroke cases and 25 643 controls of European ancestry and 1353 cases and 2383 controls of African ancestry. We examined the association between depression PRS and ischemic stroke overall and with pathogenic subtypes using logistic regression analyses. Results - The depression PRS was associated with higher risk of ischemic stroke overall in both European (P=0.025) and African ancestry (P=0.011) samples from the Stroke Genetics Network. Ischemic stroke risk increased by 3.0% (odds ratio, 1.03; 95% confidence interval, 1.00-1.05) for every 1 SD increase in PRS for those of European ancestry and by 8% (odds ratio, 1.08; 95% confidence interval, 1.04-1.13) for those of African ancestry. Among stroke subtypes, elevated risk of small artery occlusion was observed in both European and African ancestry samples. Depression PRS was also associated with higher risk of cardioembolic stroke in European ancestry and large artery atherosclerosis in African ancestry persons. Conclusions - Higher polygenic risk for major depressive disorder is associated with increased risk of ischemic stroke overall and with small artery occlusion. Additional associations with ischemic stroke subtypes differed by ancestry.",
keywords = "Atherosclerosis, Depression, Genetics, Risk, Stroke",
author = "Sylvia Wassertheil-Smoller and Qibin Qi and Tushar Dave and Mitchell, {Braxton D.} and Jackson, {Rebecca D.} and Simin Liu and Ki Park and Joel Salinas and Dunn, {Erin C.} and Leira, {Enrique C.} and Huichun Xu and Kathleen Ryan and Smoller, {Jordan W.}",
note = "Funding Information: This study was supported in part by the National Institutes of Health (NIH) grants U01 NS069208 and R01 NS100178. Dr Wassertheil-Smoller is partially funded by National Heart, Lung, and Blood Institute (NHLBI) Women's Health Initiative (WHI), one of the cohorts that contributed data to the National Institute of Neurological Disorders and Stroke SiGN study (Stroke Genetics Network). The WHI program is funded by the NHLBI, NIH, US Department of Health and Human Services, through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. Dr Salinas is supported by NIH grant T32NS048005 and by the Robert Katzman Research Training Fellowship in Alzheimer's and Dementia Research Cosponsored by the American Academy of Neurology, the American Brain Foundation, and the Alzheimer's Association. Dr Dunn is supported by NIH grant K01 MH102403. Dr Smoller is a partially supported as a Tepper Family MGH Research Scholar. Funding Information: This study was supported in part by the National Institutes of Health (NIH) grants U01 NS069208 and R01 NS100178. Funding Information: Dr Wassertheil-Smoller is partially funded by National Heart, Lung, and Blood Institute (NHLBI) Women{\textquoteright}s Health Initiative (WHI), one of the cohorts that contributed data to the National Institute of Neurological Disorders and Stroke SiGN study (Stroke Genetics Network). The WHI program is funded by the NHLBI, NIH, US Department of Health and Human Services, through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201 600004C. Dr Salinas is supported by NIH grant T32NS048005 and by the Robert Katzman Research Training Fellowship in Alzheimer{\textquoteright}s and Dementia Research Cosponsored by the American Academy of Neurology, the American Brain Foundation, and the Alzheimer{\textquoteright}s Association. Dr Dunn is supported by NIH grant K01 MH102403. Dr Smoller is a partially supported as a Tepper Family MGH Research Scholar. Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",
year = "2018",
doi = "10.1161/STROKEAHA.117.018857",
language = "English (US)",
volume = "49",
pages = "543--548",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}