Platelet Activity in Pathogenesis of Atherosclerosis

Edward R. Burns, Robert J. Friedman, Melvin L. Tiell, Theodore H. Spaet, Michael B. Stemerman, Russell Ross, John Glomset

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: Ross and Glomset are to be congratulated for their extensive review emphasizing “the importance of smooth-muscle cell proliferation as a key event” in the pathogenesis of atherosclerosis.1Since they have kindly cited the work of our laboratory, we should like to report the most recent fruits of our investigations. The authors argue that platelet-derived serum factors are responsible for stimulating intimal cell proliferation after endothelial injury. Although we have confirmed the importance of platelets in the “injury-arteriosclerosis” schema, we have demonstrated that their role is limited. Whereas platelet factors are capable of initiating smooth-muscle cell mitosis. . .

Original languageEnglish (US)
Pages (from-to)1199-1200
Number of pages2
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 18 1976

ASJC Scopus subject areas

  • General Medicine


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