Abstract
Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 919-922 |
| Number of pages | 4 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
- Virology
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