Plasma R Binder Deficiency

Ralph Carmel, Samuel H. Sigal, Charles A. Hall, Jack P. Antel, Yves Robitaille

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: Another perspective on the report on plasma R binder deficiency and neurologic disease (Nov. 19 issue)1 may be useful. The authors' construction of a parallel between their case and my four cases of R binder deficiency2 3 4 is problematic for several reasons. To begin with, the two disease entities were not the same. My patients (and one described by Zittoun et al.5) lacked R binder in all fluids and tissues, as required for the diagnosis of true R binder deficiency, whereas the patient of Sigal et al. did not. Universal absence suggests a hereditary abnormality of R.

Original languageEnglish (US)
Pages (from-to)1401-1402
Number of pages2
JournalNew England Journal of Medicine
Issue number21
StatePublished - May 26 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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