Planar cell polarity in drosophila

Saw Myat Thanda W. Maung, Andreas Jenny

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


In all multicellular organisms, epithelial cells are not only polarized along the apical-basal axis, but also within the epithelial plane, giving cells a sense of direction. Planar cell polarity (PCP) signaling regulates establishment of polarity within the plane of an epithelium. The outcomes of PCP signaling are diverse and include the determination of cell fates, the generation of asymmetric but highly aligned structures, such as the stereocilia in the human inner ear or the hairs on a fly wing, or the directional migration of cells during convergence and extension during vertebrate gastrulation. In humans, aberrant PCP signaling can result in severe developmental defects, such as open neural tubes (spina bifida), and can cause cystic kidneys. In this review, we discuss the basic mechanism and more recent findings of PCP signaling focusing on Drosophila melanogaster, the model organism in which most key PCP components were initially identified.

Original languageEnglish (US)
Issue number3
StatePublished - 2011


  • Abdomen
  • Dachsous
  • Drosophila
  • Eye
  • Fat
  • Fizzled
  • Non-canonical Wnt signaling
  • Planar cell polarity
  • Protein asymmetry
  • Wing

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation


Dive into the research topics of 'Planar cell polarity in drosophila'. Together they form a unique fingerprint.

Cite this