Phagocytic signaling strategies: Fcγ receptor-mediated phagocytosis as a model system

Dianne Cox; Steven Greenberg

doi:10.1006/smim.2001.0330

Phagocytic signaling strategies: Fc_γ receptor-mediated phagocytosis as a model system

Dianne Cox
, Steven Greenberg

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 μ m. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc_γ Rs).

Original language	English (US)
Pages (from-to)	339-345
Number of pages	7
Journal	Seminars in Immunology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1006/smim.2001.0330
State	Published - 2001
Externally published	Yes

Keywords

Actin
Fcreceptors
Syk
Tyrosine kinase

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1006/smim.2001.0330

Cite this

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title = "Phagocytic signaling strategies: Fcγ receptor-mediated phagocytosis as a model system",

abstract = "Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 μ m. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fcγ Rs).",

keywords = "Actin, Fcreceptors, Syk, Tyrosine kinase",

author = "Dianne Cox and Steven Greenberg",

note = "Funding Information: This work was supported by grants from the National Institutes of Health. SG is an Established Investigator of the American Heart Association.",

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KW - Fcreceptors

KW - Syk

KW - Tyrosine kinase

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