Abstract
Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 440-444 |
| Number of pages | 5 |
| Journal | Clinical Biochemistry |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| State | Published - Apr 2012 |
| Externally published | Yes |
Keywords
- Antioxidant system
- Global oxidative stress
- Glutathione redox system
- Multiple sclerosis
- Oxidative stress
ASJC Scopus subject areas
- Clinical Biochemistry
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