Perineuronal nets in memory

Hui Zhang; Ana Cicvaric; Thomas E. Bassett; Elizabeth M. Wood; Zorica Petrovic; Jelena Radulovic

doi:10.1016/B978-0-443-15754-7.00066-3

Perineuronal nets in memory

Hui Zhang
, Ana Cicvaric
, Thomas E. Bassett
, Elizabeth M. Wood
, Zorica Petrovic
, Jelena Radulovic

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Perineuronal nets (PNN) are specialized structures surrounding certain nerve cells. Although considered as a part of the extracellular matrix (ECM), they are composed of sugars stemming from the cells they surround as well as of extracellular glycoproteins. PNN are formed after birth, through interactions of intrinsic genetic programs and experience-dependent activity. Their occurrence marks the end of heightened plasticity typical of early brain development and coincides with the maturation of memory circuits, especially with their capacity to retain memories over long periods of time. Manipulations of PNN are extensively researched for their potential to alleviate memory deficits of neuropsychiatric disorders.

Original language	English (US)
Title of host publication	Learning and Memory
Subtitle of host publication	A Comprehensive Reference
Publisher	Elsevier
Pages	V2:453-V2:475
ISBN (Electronic)	9780443157547
ISBN (Print)	9780443157554
DOIs	https://doi.org/10.1016/B978-0-443-15754-7.00066-3
State	Published - Jan 1 2025

Keywords

Amygdala
Cerebellum
Chondroitin sulfate proteoglycans
Classical conditioning
Cortex
Episodic memory
Hippocampus
Hyaluronan
Link proteins
Neurodegenerative disorders
Object recognition
Perineuronal nets
Psychiatric disorders
Spatial memory
Tenascins critical period

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-0-443-15754-7.00066-3

Cite this

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abstract = "Perineuronal nets (PNN) are specialized structures surrounding certain nerve cells. Although considered as a part of the extracellular matrix (ECM), they are composed of sugars stemming from the cells they surround as well as of extracellular glycoproteins. PNN are formed after birth, through interactions of intrinsic genetic programs and experience-dependent activity. Their occurrence marks the end of heightened plasticity typical of early brain development and coincides with the maturation of memory circuits, especially with their capacity to retain memories over long periods of time. Manipulations of PNN are extensively researched for their potential to alleviate memory deficits of neuropsychiatric disorders.",

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AU - Zhang, Hui

AU - Cicvaric, Ana

AU - Bassett, Thomas E.

AU - Wood, Elizabeth M.

AU - Petrovic, Zorica

AU - Radulovic, Jelena

PY - 2025/1/1

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KW - Amygdala

KW - Cerebellum

KW - Chondroitin sulfate proteoglycans

KW - Classical conditioning

KW - Cortex

KW - Episodic memory

KW - Hippocampus

KW - Hyaluronan

KW - Link proteins

KW - Neurodegenerative disorders

KW - Object recognition

KW - Perineuronal nets

KW - Psychiatric disorders

KW - Spatial memory

KW - Tenascins critical period

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BT - Learning and Memory

PB - Elsevier

ER -

Perineuronal nets in memory

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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