Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis

Azeem Latib, Matteo Montorfano, Filippo Figini, Francesco Maisano, Alaide Chieffo, Stefano Benussi, Raimondo Bellanca, Chiara Gerli, Pietro Spagnolo, Ottavio Alfieri, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation.

Original languageEnglish (US)
Pages (from-to)397-398
Number of pages2
JournalJournal of Cardiovascular Medicine
Issue number6
StatePublished - Jun 2012
Externally publishedYes


  • radiation-induced aortic stenosis
  • small aortic annulus
  • transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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