TY - JOUR
T1 - Peptide-Based Vaccines
T2 - Current Progress and Future Challenges
AU - Malonis, Ryan J.
AU - Lai, Jonathan R.
AU - Vergnolle, Olivia
N1 - Funding Information:
J.R.L. gratefully acknowledges funding from the NIH (R01-AI125462 R01-AI132256, and R42-AI122403) as well as the Irma T. Hirschl Trust. R.J.M. was supported in part by the Einstein Medical Scientist Training Program (T32-GM007288).
Funding Information:
J.R.L. gratefully acknowledges funding from the NIH (R01-AI125462, R01-AI132256, and R42-AI122403) as well as the Irma T. Hirschl Trust. R.J.M. was supported in part by the Einstein Medical Scientist Training Program (T32-GM007288).
Funding Information:
Jonathan Lai received his B.Sc. (Hons.) in Biochemistry from Queen’s University (Kingston, Ontario, Canada) in 1999, and his Ph.D. in 2004 in Biophysics and Chemistry from the University of Wisconsin-Madison where he trained with Professor Samuel H. Gellman as a Natural Sciences and Engineering Research Council (NSERC) of Canada PGS B scholar. He was the Helen Hay Whitney postdoctoral fellow from 2004–2007 in Biological Chemistry at Harvard Medical School where he worked in the groups of Professor Christopher T. Walsh and Stephen C. Harrison. He began his independent faculty position at the Albert Einstein College of Medicine in 2007, where he is currently Professor of Biochemistry. He is the recipient of the Arnold and Mabel Young Investigator Award, and the Irma T. Hirschl/Monique Weill-Caulier Career Scientist Award. Professor Lai’s group is broadly interested in protein engineering and antibody isolation strategies for the development of novel immunotherapies and vaccines.
Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2020/3/25
Y1 - 2020/3/25
N2 - Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.
AB - Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.
UR - http://www.scopus.com/inward/record.url?scp=85076321498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076321498&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrev.9b00472
DO - 10.1021/acs.chemrev.9b00472
M3 - Review article
C2 - 31804810
AN - SCOPUS:85076321498
SN - 0009-2665
VL - 120
SP - 3210
EP - 3229
JO - Chemical Reviews
JF - Chemical Reviews
IS - 6
ER -
